-set of the substanes whih are being fabris of an organism, being predeessors kininov and kallikreinov, and also ativators and ingibitorami their transformations, at driving to formation{eduation} and the subsequent destrution kininov .-to. Partiipates in regulation of a tone and permeability of a vasular wall and plays the important role in patogeneze inflammations and allergi reations.